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Probiotics and Acne – A Holistic Approach to Acne Treatment
Added:2023-11-23
Facial skin is a unique showcase for every person. It's a part of our image, defining our identity, making us unique and exceptional. Acne, as a skin condition, negatively impacts well-being, often lowering self-esteem, especially since it most often appears during adolescence—a time full of contradictions, but also an intense stage of identity building, with exceptional sensitivity in shaping one's position in the peer group. Skin lesions are often considered a superficial condition resulting from hormonal imbalances. The cause, however, boils down to a common problem attributed to adolescents. This doesn't seem entirely accurate, as the condition often appears after the age of 40. So why does this happen?
Acne, the terror of teenagers?
Acne vulgaris is an inflammatory skin condition characterized by the appearance of eruptions such as blackheads, pustules, papules, and cysts. The most commonly cited factors contributing to this skin condition include:
• abnormal keratinization of the sebaceous ducts,
• bacterial colonization (Cutibacterium Acnes),
• increased sebum production,
• genotypic factors,
• hormonal disorders.
Due to the fact that many changes occur in a young person's body, including in the hormonal system, and other factors such as stress and mood swings that affect a teenager's well-being and functioning, acne is commonly considered a symbol of adolescence.
Currently, there is a wealth of research on this condition, pointing to a more complex problem that doesn't have a single cause, but rather is influenced by many interconnected factors. Furthermore, the issue of adult acne is becoming increasingly common, with people over 40 suffering from it even if they haven't previously had the problem.
Cutibacterium Acnes – is it the main “culprit” of acne?
The most likely pathogen of acne is the bacterium Cutibacterium acnes. It occurs most often in sebum-rich areas such as the scalp, face, chest, and back.
It is worth mentioning that the skin microflora consists mainly of bacteria belonging to three types:
• Corynebacteria,
• Cutibacterium acnes,
• Staphylococci.
The interplay between members of the skin microbiota is essential for maintaining healthy skin. Although C. acnes predominates in sebaceous areas, it plays a key role in regulating skin homeostasis and preventing colonization by other harmful pathogens; in the case of acne vulgaris, it can also act as an opportunistic pathogen (microorganisms that cause infections only in immunocompromised individuals). New findings show that, contrary to previous belief, the presence of C. acnes itself is not the cause of acne, but rather an imbalance between members of the skin microbiota and between individual strains of this particular bacterium.
Studies have shown that acne-prone skin does not harbor higher numbers of C. acnes than normal skin; the relative abundance of this bacterium (in metagenomic studies) is similar in acne patients and healthy individuals (87–89%).1 Furthermore, acne has been found to be caused not only by the specific C. acnes strain but also by host and environmental factors, which may potentially cause varying levels of innate immune activation in severe acne. Furthermore, factors such as diet, stress, and the gut microbiome also influence the course, intensity, and duration of the disease.
How to support acne treatment with diet?
Research shows a link between acne and the consumption of foods with a high glycemic index, which affects insulin levels. This hormone plays a key role in carbohydrate metabolism and regulates blood glucose levels. High insulin levels increase the production of growth hormone (GH), which in turn leads to increased IGF-1. Increased levels of this hormone trigger sebum production and the growth of sebaceous gland cells, thus contributing to the development of acne.
One of the first studies on dietary intervention in the treatment of acne vulgaris was conducted in 2007 by Smith and colleagues. Forty-three men aged 15–25 with moderate acne received low-glycemic load meals for 12 weeks. After this period, the number of acne lesions, sex hormone levels, and insulin markers were compared with those at the beginning of treatment. The study showed significant improvements in the occurrence and course of acne.2 This suggests that changing diet and eating habits can have a beneficial and supportive effect on the treatment of skin lesions. Furthermore, a diet high in simple sugars and highly processed foods disrupts intestinal function and, consequently, affects skin quality, as the existence of a gut-skin axis has been proven.
Guts and acne. What's the connection?
Both acne and the health of the digestive tract are linked to the quality of the gut microbiome. The skin and intestines are highly vascularized and innervated, and they perform neuroendocrine and immune functions, among other functions.
A growing body of research points to the interdependence of these two organs. Russian scientists studied 114 patients with acne vulgaris and observed that 54% of acne patients had differences in their gut flora. Furthermore, they found that administering probiotics to patients with acne and gut dysbiosis shortened the duration of treatment.
The existence of the gut-skin axis is evidenced by many factors. In addition to acting through the immune system, metabolic products and microbial compounds can affect the intestinal epithelium, altering its physiology. This ultimately leads to the production of various secretory products that circulate throughout the body, including the skin. Therefore, chemical compounds delivered through food can have an immediate impact on the appearance and quality of the skin.
Also worth noting is the mechanism of acne treatment, which relies heavily on antibiotics. This creates a vicious cycle. While commonly used treatments can indeed alleviate acne symptoms, they also cause numerous negative side effects. Oral antibiotics destroy the digestive system's bacterial flora, weaken the intestines, and kill beneficial bacteria. This creates a vicious cycle in which the chosen solution helps with one problem but damages the other. So, is there a proven, effective way to deal with skin problems?
How to get rid of acne?
The beneficial effects of lactic acid bacteria, which normally inhabit the gut, in treating acne were recognized as early as the 1930s, when doctors used oral supplementation of Lactobacillus acidophilus for this condition. In a 1961 study, patients were given a probiotic for 16 days, with a two-week break after the first eight days. Eighty percent of acne patients experienced improvement in their skin appearance, with the improvement being most noticeable in those with severe inflammatory acne.
Furthermore, oral probiotics have been shown to reduce inflammation and oxidative stress. Furthermore, they can alter the microbial community in places outside the digestive tract, thus also impacting skin condition and acne.4 Studies show that probiotic use can reduce skin eruptions. Furthermore, it positively impacts the gut microflora, which is responsible for immunity and plays a key role in combating pathogenic conditions in the human body.
Which probiotic to help fight acne should you choose?
A probiotic should contain live cultures of the bacterium Lactobacillus acidophilus. A wide range of probiotic supplements is available in the pharmaceutical and cosmetic markets (where the benefits of probiotics are also beginning to be recognized).
It is worth paying attention to the viability of a given strain. Lactobacillus acidophilus Er-2 strain 317/402 Narine has been shown to be highly effective in clinical trials because it is resistant to stomach acids and, as a result, reaches the intestines, settling on their walls.
It's important to remember that properly cared for intestinal microflora offers a number of benefits, including facilitating the absorption of vitamins and trace elements, which are essential for maintaining healthy skin, for example.
This means that using a probiotic with the Narine bacterium also increases the effectiveness of other supplements, e.g. vitamins, through significantly better absorption.
Holistic acne treatment
1. Detoxification.
Regular cleansing of the body is essential to maintaining internal balance.
Narum OFFToxic forte is a combination of tansy and clove extract with a metabiotic.
Dosage: for the first week (7 days): 1 capsule, 2 times a day.
For the next 2 weeks (14 days): 2 capsules, 2 times a day.
Detox is a composition of 20 freeze-dried products that support intestinal microflora. Take 2 capsules twice daily.
Candid Matsun in capsule form is used to maintain the composition and biological activity of normal intestinal microflora in children and adults and has been known for 5 thousand years in one of the mountainous regions of Armenia .
Dosage: Days 1–7: 1 capsule 2 times daily. Days 8–22: 2 capsules 2 times daily.
The products should be taken together. For optimal results, it is recommended to use the products for a minimum of 21 days. The set helps cleanse the body, regain energy, and improve well-being.
2. Rebuilding the intestinal bacterial flora.
Probiotics with Narine bacteria are highly effective in restoring intestinal flora. Narum Fast contains Narine bacteria and a metabiotic, while Narum Forte contains non-pathogenic E. coli bacteria.
Use:
Stage I: Narum Fast until the end of the packaging,
Stage II: Narum Forte until the end of the packaging,
Stage III: Narum Plus until the end of the packaging.
Dosage for adults and children over 12 years:
• Narum Fast - 2 capsules 3 times a day, 15-20 minutes before a meal,
• Narum Forte - 2 capsules 3 times a day, 15-20 minutes before a meal,
• Narum Plus - 2 capsules 3 times a day, 15-20 minutes before a meal.
3. Micro and macro elements.
White Acidophilic Mumio will strengthen the body and care for the skin. Far Eastern medicine points to the beneficial effects of white mumio and supports beautiful skin care. White Mumio contains micro and macro elements, the bacterium Lactobacterium mazuni "Karine" (Page 2), and the highly bioavailable acidophilic form.
Receiving:
• adults and children over 6 years of age: 1-2 capsules 2 times a day,
• children from 3 to 6 years of age: 1 capsule 2 times a day (after dissolving in a drink).
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Bibliography:
1 Cutibacterium acnes ( Propionibacterium acnes ) and acne vulgaris: a brief look at the latest updates B. Dréno, S. Pecastaings, S. Corvec, S. Veraldiego, A. Khammari, C. Roquesa, 2018.
2,3,4 Edible plants and their impact on the gut microbiome and acne Ashley K. Clark, Kelly N. Haas, and Raja K. Sivamani, 2017.
Microbiome and probiotics in acne vulgaris — a narrative review, Karolina Chilicka, Iwona Dzieńdziora-Urbińska, Renata Szyguła, Binnaz Asanova and Danuta Nowicka March 2022.
Skin microbiome and the gut-cutaneous axis, Shivani Sinha MS ,Gloria Lin MS, 2021.
The Impact of Gut Microbiome on Skin Health: The Gut-Skin Axis Observed Through the Prism of Therapy and Skin Diseases Ms. Rayhan Mahmud, Sharmin Akter, Sanjida Khanam Tamanna, Lincon Mazumder, Israt Zahan Esti, Sanchita Banerjee, Sumona Akter, Md. Rakibul Hasan, Mrityunjoy Acharjee, Md. Sajjad Hossain and Anna Maria Pirttilä, 2022.
Probiotics in Acne-Prone Skin Care. A Review of the Latest Scientific Reports, Natalia Kurkowska 2021.
The influence of intestinal microbiota disorders on the occurrence of skin diseases, Marta Janoska, 2022.