What is Lizozim?

The mucous membrane of the oral cavity, conjunctiva and respiratory tract, i.e. in organs constantly exposed to various types of microorganisms, contains lysozyme - a protein enzyme that is of great importance in building immunity.

What exactly is lysozyme?

Lysozyme is a widely distributed protein with a low molecular weight (14,000 Da). Due to its low weight, it participates in the non-specific immune response of the body, i.e. in the first reaction to a pathogenic factor. Lysozyme occurs in a large number of tissues, organs and biological fluids of representatives of the kingdoms of living organisms, which means that it also occurs in humans and animals. Its natural substrate is the cell membranes of bacteria.

Fun fact
Lysozyme was discovered in 1921 by the Scottish microbiologist Alexander Fleming (the same one known for inventing penicillin). He observed the reaction that occurred after a drop of nasal mucus combined with an agar medium – this led to lysis, or the disintegration of the bacteria growing on it. In this way, Fleming discovered a bacteriolytic factor and the following year gave it the name lysozyme . (Gajda, Bugla-Płoskońska, 2014)

Properties of lysozyme

Lysozyme can withstand boiling for up to 3 minutes, its optimum temperature is +60°C. In dried form, it withstands 2-hour sterilization at +160°C. Lysozyme is not afraid of acidic environments, but is unstable in alkaline ones – it shows the greatest activity at pH between 5 and 7. UV radiation can inactivate it very quickly.

Lysozyme mechanism of action

The therapeutic effect of lysozyme is based on its antimicrobial properties, which depend on its enzymatic activity. It has the ability to partially or even completely break down the cell membranes of microorganisms, i.e. fungi:

• Mucopeptides - gram positive bacteria;
• staphylococci ( Staphylococcus ),
• streptococci ( Streptococcus ),
• tetanus bacilli ( Clostridium tetani ),
• gas gangrene bacilli ( Clostridium perfringens ),
• anthrax bacilli ( Bacillus anthracis ),
• diphtheria corynebacteria ( Corynebacterium diphtheriae ),
• Mycobacterium tuberculosis ,
• Mycobacterium leprae ,
• Listeria monocytogenes bacilli ).

It has a particular effect on saprophytes, but also has a positive effect on other pathogenic strains. The action of lysozyme leads to the formation of a large number of holes in cell membranes, and the structural components inside are disorganized. The enzyme lysozyme slows down the reproduction of viral particles by stimulating the production of interferon in tissues. Interferon plays an extremely important role in the immune process.

Lysozyme belongs to the group of bacteriolytic enzymes, i.e. it has the ability to dissolve some bacteria. It has analgesic effects, stimulates tissue and cell regeneration. It also has antimicrobial effects, enhanced by combination with antibacterial drugs (especially streptomycin). It participates in regenerative processes, the creation of immunity and the healing of damage to the oral mucosa.

Fun fact
The process of licking young, which is common among mammals, is associated with the transfer of lysozyme from the mother. During licking, a protective barrier is created on the young animal's body. Thanks to its low molecular weight, the lysozyme enzyme and other nutrients penetrate the animal's body through the skin. Thanks to lysozyme, its skin acquires bacteriolytic (bacteria-dissolving) abilities, which results in an automatic increase in immunity.

What is Lizozim ?

It is a fermented high-protein drink containing milk proteins Lactobacillus acidophilus strain Er-2 317/402 Narine as well as magnesium and calcium. Lizozimo is an energy-boosting product, which literally translates from Russian as a tool that increases energy. The energy-boosting effect is related to the regulation of energy metabolism and the stimulation of the functioning of the human brain. This topic is explored more widely in the East, where energy-boosting therapy is used in treatment. In Poland, such a drink is said to be a means that stimulates the sympathetic nervous system, which leads to increased energy, greater activity and readiness to act [1,2,3].

The preparation is obtained during the biotechnological production process of metabiotics of the bacteria Lactobacillus acidophilus Er-2 strain 317/402 Narine . Its characteristic feature is the appropriately high content of lysozyme , additionally it contains a range of other substances and amino acids: serine, tryptophan, methionine, glutamic acid, valine, histidine, leuchine, isoleucine, ascorbic acid (vit. C), riboflavin (vit. B2), thiamine (vit. B1), pyridoxine (vit. B6), tocopherol (vit. E), vitamin D3, vitamin A, lactic acid, AMP (antimicrobial peptides): bacteriocins, acidocins.   Magnesium and calcium help maintain the proper functioning of the nervous system. Additionally, magnesium helps reduce the feeling of tiredness and fatigue.

Fun fact
On the third day of feeding, cows feed their young with lysozyme. At that time, its content in milk increases to as much as 30 μg/ml – this translates into the destruction of bacterial cells and the regeneration of affected tissues, i.e. specific support for the calves' immunity.

Benefits of using Lizozim?

Lizozimmo , thanks to the content of lysozyme and a large amount of other vitamins and amino acids, has a positive effect on the human body. It has a stimulating effect on the immune system, mobilizes the non-specific , i.e. first defense reaction of the body . The preparation supports the functioning of the circulatory system by participating in the process of hematopoiesis, i.e. blood production. The ingredients of lizozimo also have bactericidal properties (lysozyme has the ability to destroy bacteria), antitoxic and anti-inflammatory . It also supports cell regeneration , as well as facilitates the healing process of wounds . In addition causes the growth of lactic acid bacteria that live in the intestine, their native environment.

Lizozim is indicated as:

• a preparation that improves immunity,
• a tool that stimulates a non-specific immune response,
• anti-inflammatory and bactericidal agent,
• support of the hematopoietic process,
• cell regeneration stimulator,
• a preparation supporting wound healing,
• antitoxic agent.

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Sources:
1.Neudakhin EV, Talitskaya OE Energy therapy of psychoemotional disorders in children and adolescents with autonomic dystonia. breast cancer. Mother and Child. 2021;4(1):77-84. DOI: 10.32364/2618-8430-2021-4-1-77-84. ригинальная статья published on the website РМЖ (Русский медицинский журнал): http://www.rmj.ru/articles/pediatriya/Energotropnaya_terapiya_psihoemocionalynyh_rasstroystv_u_detey_i_podrostkov_s_vegetativnoy_distoniey/#ixzz7kzSUgKbT Under Creative Commons License: Attribution
2. Prusiński A., Fundamentals of clinical neurology., Warsaw: PZWL, 1977, p. 66 https://pl.wikipedia.org/wiki/Sympatykotonia
3. https://5prawnatury.pl/metody-terapeutyczne-2/
4. https://www.dine4fit.pl/emulgator/e1105
5. Gajda E., Bugla-Płoskońska G., Lysozyme – occurrence in nature, biological properties and possible applications , Postepy Hig Med Dosw (online), 2014; 68: 1501-1515 e-ISSN 1732-2693